Evaluation of Hair Follicles as a Surrogate Tissue for Pharmacodynamic Response in Xenograft Tumors
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چکیده
OF THESIS Submitted in partial fulfillment of the requirements for the degree of Master of Science in Biology in the Graduate School of Arts and Science of Northeastern University, March 2012
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Can Dev for Top
Downloa pose: Phosphorylated histone H2AX (γH2AX) serves as a biomarker for formation of DNA doublebreak repair complexes. A quantitative pharmacodynamic immunofluorescence assay for γH2AX eveloped, validated, and tested in human tumor xenograft models with the use of clinically relevant ures. erimental Design: The γH2AX immunofluorescence assay uses a novel data quantitation and imocessing alg...
متن کاملDevelopment of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity.
PURPOSE Phosphorylated histone H2AX (γH2AX) serves as a biomarker for formation of DNA double-strand break repair complexes. A quantitative pharmacodynamic immunofluorescence assay for γH2AX was developed, validated, and tested in human tumor xenograft models with the use of clinically relevant procedures. EXPERIMENTAL DESIGN The γH2AX immunofluorescence assay uses a novel data quantitation a...
متن کاملcer Therapy : Preclinical elopment of a Validated Immunofluorescence Assay γ H 2 AX as a Pharmacodynamic Marker of R oisomerase I Inhibitor Activity
Download pose: Phosphorylated histone H2AX (γH2AX) serves as a biomarker for formation of DNA doublebreak repair complexes. A quantitative pharmacodynamic immunofluorescence assay for γH2AX eveloped, validated, and tested in human tumor xenograft models with the use of clinically relevant ures. erimental Design: The γH2AX immunofluorescence assay uses a novel data quantitation and imocessing al...
متن کاملP-121: Follicle Development in Vitrified Sheep Ovarian Tissue Transplanted to Immunodeficiencent Rat
Background: Ovarian cortex xenotransplantation into immunodeficient rats is a follicles protection method in rare animals and investigation on folliclogenesis. The aim of this study was to evaluate the effects of gonadotropin and erythropoietin (EPO) treatment on follicular development in the transplanted ovaries. Materials and Methods: Prepared sheep ovarian cortical strips were vitrified by c...
متن کاملAssessment of chk1 phosphorylation as a pharmacodynamic biomarker of chk1 inhibition.
PURPOSE Chk1 inhibitors, such as AZD7762, are in clinical development in combination with cytotoxic agents for the treatment of solid tumors, including pancreatic cancers. To maximize the likelihood of their clinical success, it is essential to optimize drug scheduling as well as pharmacodynamic biomarkers in preclinical models. EXPERIMENTAL DESIGN We tested multiple schedules of administrati...
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تاریخ انتشار 2014